Age-related changes in microvascular blood flow and transcutaneous oxygen tension under Basal and stimulated conditions.
Identifieur interne : 004114 ( Main/Exploration ); précédent : 004113; suivant : 004115Age-related changes in microvascular blood flow and transcutaneous oxygen tension under Basal and stimulated conditions.
Auteurs : Rajna Ogrin [Australie] ; Peteris Darzins ; Zeinab KhalilSource :
- The journals of gerontology. Series A, Biological sciences and medical sciences [ 1079-5006 ] ; 2005.
Descripteurs français
- KwdFr :
- Acétylcholine (pharmacologie), Adulte (MeSH), Adulte d'âge moyen (MeSH), Capsaïcine (pharmacologie), Cellules réceptrices sensorielles (physiologie), Femelle (MeSH), Fluxmétrie laser Doppler (MeSH), Humains (MeSH), Microcirculation (physiologie), Mâle (MeSH), Oxygène (sang), Peau (vascularisation), Pression partielle (MeSH), Sujet âgé (MeSH), Surveillance transcutanée des gaz du sang (MeSH), Vasodilatateurs (pharmacologie), Vieillissement (physiologie).
- MESH :
- pharmacologie : Acétylcholine, Capsaïcine, Vasodilatateurs.
- physiologie : Cellules réceptrices sensorielles, Microcirculation, Vieillissement.
- sang : Oxygène.
- vascularisation : Peau.
- Adulte, Adulte d'âge moyen, Femelle, Fluxmétrie laser Doppler, Humains, Mâle, Pression partielle, Sujet âgé, Surveillance transcutanée des gaz du sang.
English descriptors
- KwdEn :
- Acetylcholine (pharmacology), Adult (MeSH), Aged (MeSH), Aging (physiology), Blood Gas Monitoring, Transcutaneous (MeSH), Capsaicin (pharmacology), Female (MeSH), Humans (MeSH), Laser-Doppler Flowmetry (MeSH), Male (MeSH), Microcirculation (physiology), Middle Aged (MeSH), Oxygen (blood), Partial Pressure (MeSH), Sensory Receptor Cells (physiology), Skin (blood supply), Vasodilator Agents (pharmacology).
- MESH :
- chemical , blood : Oxygen.
- chemical , pharmacology : Acetylcholine, Capsaicin, Vasodilator Agents.
- blood supply : Skin.
- physiology : Aging, Microcirculation, Sensory Receptor Cells.
- Adult, Aged, Blood Gas Monitoring, Transcutaneous, Female, Humans, Laser-Doppler Flowmetry, Male, Middle Aged, Partial Pressure.
Abstract
BACKGROUND
Adequate cutaneous microvascular blood flow and tissue oxygen tension are important prerequisites for successful tissue repair. The efficacy of tissue repair decreases with age and is linked to the age-related functional decline of unmyelinated sensory neurons that are important for inflammation and tissue repair. However, available information on the effect of these neuronal changes on microvascular blood flow and tissue oxygen tension is limited, particularly under control and injury conditions. The authors had two aims in this study: (a) to assess age-related changes in the relationship between microvascular blood flow and tissue oxygen perfusion under basal and two different stimulated conditions (sensory dependent and sensory independent), and (b) to clarify the biological meaning of transcutaneous partial pressure of oxygen (tcPO2) measurements.
METHODS
The effects of a sensory-independent vasodilator (acetylcholine) and a sensory-dependent vasodilator (capsaicin) on microvascular blood flow and oxygen perfusion in persons of different ages were measured. Laser Doppler flowmetry and a commercially available transcutaneous oxygen monitor (with sensors set at 39 degrees C and 44 degrees C) were used. Healthy volunteers were recruited: 11 young, 14 middle aged, and 19 older.
RESULTS
Under basal conditions (skin temperature, 37 degrees C to 39 degrees C), both basal blood flow and tcPO2 increased with increasing age. However, with the sensor set at 44 degrees C, tcPO2 showed a significant decrease with age. Acetylcholine increased blood flow approximately equally in the three age groups. Capsaicin increased blood flow and tcPO2 in all age groups, with the young showing a greater increase compared with the older participants.
CONCLUSIONS
The age-associated changes in basal and stimulated microvascular blood flow and tcPO2 could be attributed in part to altered neuronal function. Measuring tcPO2 at 39 degrees C showed a trend toward an increase with age. In contrast, a decrease with age was observed when tcPO2 was measured at 44 degrees C, a temperature sufficient to activate sensory nerve endings. The results may reflect a decline in sensory nerve function with age rather than a decrease in oxygen delivery for vascular reasons. This is supported by the complementary data showing a significant age-related decrease in stimulated blood flow in response to capsaicin, with no change in the response to the sensory-independent vasodilator acetylcholine. Thus, for clinical purposes, data obtained using the tcPO2 monitor should be interpreted with full knowledge of the conditions under which the measurements were made. Furthermore, for scientific purposes, the tcPO2 monitor could be used to assess sensory nerve function when sensors are heated to 44 degrees C.
DOI: 10.1093/gerona/60.2.200
PubMed: 15814863
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Series A, Biological sciences and medical sciences</title><idno type="ISSN">1079-5006</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholine (pharmacology)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aging (physiology)</term><term>Blood Gas Monitoring, Transcutaneous (MeSH)</term><term>Capsaicin (pharmacology)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Laser-Doppler Flowmetry (MeSH)</term><term>Male (MeSH)</term><term>Microcirculation (physiology)</term><term>Middle Aged (MeSH)</term><term>Oxygen (blood)</term><term>Partial Pressure (MeSH)</term><term>Sensory Receptor Cells (physiology)</term><term>Skin (blood supply)</term><term>Vasodilator Agents (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétylcholine (pharmacologie)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Capsaïcine (pharmacologie)</term><term>Cellules réceptrices sensorielles (physiologie)</term><term>Femelle (MeSH)</term><term>Fluxmétrie laser Doppler (MeSH)</term><term>Humains (MeSH)</term><term>Microcirculation (physiologie)</term><term>Mâle (MeSH)</term><term>Oxygène (sang)</term><term>Peau (vascularisation)</term><term>Pression partielle (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Surveillance transcutanée des gaz du sang (MeSH)</term><term>Vasodilatateurs (pharmacologie)</term><term>Vieillissement (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acetylcholine</term><term>Capsaicin</term><term>Vasodilator Agents</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Skin</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acétylcholine</term><term>Capsaïcine</term><term>Vasodilatateurs</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules réceptrices sensorielles</term><term>Microcirculation</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Microcirculation</term><term>Sensory Receptor Cells</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Oxygène</term></keywords><keywords scheme="MESH" qualifier="vascularisation" xml:lang="fr"><term>Peau</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blood Gas Monitoring, Transcutaneous</term><term>Female</term><term>Humans</term><term>Laser-Doppler Flowmetry</term><term>Male</term><term>Middle Aged</term><term>Partial Pressure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Fluxmétrie laser Doppler</term><term>Humains</term><term>Mâle</term><term>Pression partielle</term><term>Sujet âgé</term><term>Surveillance transcutanée des gaz du sang</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Adequate cutaneous microvascular blood flow and tissue oxygen tension are important prerequisites for successful tissue repair. The efficacy of tissue repair decreases with age and is linked to the age-related functional decline of unmyelinated sensory neurons that are important for inflammation and tissue repair. However, available information on the effect of these neuronal changes on microvascular blood flow and tissue oxygen tension is limited, particularly under control and injury conditions. The authors had two aims in this study: (a) to assess age-related changes in the relationship between microvascular blood flow and tissue oxygen perfusion under basal and two different stimulated conditions (sensory dependent and sensory independent), and (b) to clarify the biological meaning of transcutaneous partial pressure of oxygen (tcPO2) measurements.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The effects of a sensory-independent vasodilator (acetylcholine) and a sensory-dependent vasodilator (capsaicin) on microvascular blood flow and oxygen perfusion in persons of different ages were measured. Laser Doppler flowmetry and a commercially available transcutaneous oxygen monitor (with sensors set at 39 degrees C and 44 degrees C) were used. Healthy volunteers were recruited: 11 young, 14 middle aged, and 19 older.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Under basal conditions (skin temperature, 37 degrees C to 39 degrees C), both basal blood flow and tcPO2 increased with increasing age. However, with the sensor set at 44 degrees C, tcPO2 showed a significant decrease with age. Acetylcholine increased blood flow approximately equally in the three age groups. Capsaicin increased blood flow and tcPO2 in all age groups, with the young showing a greater increase compared with the older participants.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The age-associated changes in basal and stimulated microvascular blood flow and tcPO2 could be attributed in part to altered neuronal function. Measuring tcPO2 at 39 degrees C showed a trend toward an increase with age. In contrast, a decrease with age was observed when tcPO2 was measured at 44 degrees C, a temperature sufficient to activate sensory nerve endings. The results may reflect a decline in sensory nerve function with age rather than a decrease in oxygen delivery for vascular reasons. This is supported by the complementary data showing a significant age-related decrease in stimulated blood flow in response to capsaicin, with no change in the response to the sensory-independent vasodilator acetylcholine. Thus, for clinical purposes, data obtained using the tcPO2 monitor should be interpreted with full knowledge of the conditions under which the measurements were made. Furthermore, for scientific purposes, the tcPO2 monitor could be used to assess sensory nerve function when sensors are heated to 44 degrees C.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15814863</PMID><DateCompleted><Year>2005</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1079-5006</ISSN><JournalIssue CitedMedium="Print"><Volume>60</Volume><Issue>2</Issue><PubDate><Year>2005</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The journals of gerontology. Series A, Biological sciences and medical sciences</Title><ISOAbbreviation>J Gerontol A Biol Sci Med Sci</ISOAbbreviation></Journal><ArticleTitle>Age-related changes in microvascular blood flow and transcutaneous oxygen tension under Basal and stimulated conditions.</ArticleTitle><Pagination><MedlinePgn>200-6</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Adequate cutaneous microvascular blood flow and tissue oxygen tension are important prerequisites for successful tissue repair. The efficacy of tissue repair decreases with age and is linked to the age-related functional decline of unmyelinated sensory neurons that are important for inflammation and tissue repair. However, available information on the effect of these neuronal changes on microvascular blood flow and tissue oxygen tension is limited, particularly under control and injury conditions. The authors had two aims in this study: (a) to assess age-related changes in the relationship between microvascular blood flow and tissue oxygen perfusion under basal and two different stimulated conditions (sensory dependent and sensory independent), and (b) to clarify the biological meaning of transcutaneous partial pressure of oxygen (tcPO2) measurements.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The effects of a sensory-independent vasodilator (acetylcholine) and a sensory-dependent vasodilator (capsaicin) on microvascular blood flow and oxygen perfusion in persons of different ages were measured. Laser Doppler flowmetry and a commercially available transcutaneous oxygen monitor (with sensors set at 39 degrees C and 44 degrees C) were used. Healthy volunteers were recruited: 11 young, 14 middle aged, and 19 older.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Under basal conditions (skin temperature, 37 degrees C to 39 degrees C), both basal blood flow and tcPO2 increased with increasing age. However, with the sensor set at 44 degrees C, tcPO2 showed a significant decrease with age. Acetylcholine increased blood flow approximately equally in the three age groups. Capsaicin increased blood flow and tcPO2 in all age groups, with the young showing a greater increase compared with the older participants.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The age-associated changes in basal and stimulated microvascular blood flow and tcPO2 could be attributed in part to altered neuronal function. Measuring tcPO2 at 39 degrees C showed a trend toward an increase with age. In contrast, a decrease with age was observed when tcPO2 was measured at 44 degrees C, a temperature sufficient to activate sensory nerve endings. The results may reflect a decline in sensory nerve function with age rather than a decrease in oxygen delivery for vascular reasons. This is supported by the complementary data showing a significant age-related decrease in stimulated blood flow in response to capsaicin, with no change in the response to the sensory-independent vasodilator acetylcholine. Thus, for clinical purposes, data obtained using the tcPO2 monitor should be interpreted with full knowledge of the conditions under which the measurements were made. Furthermore, for scientific purposes, the tcPO2 monitor could be used to assess sensory nerve function when sensors are heated to 44 degrees C.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ogrin</LastName><ForeName>Rajna</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Ageing Research Institute, The University of Melbourne, Poplar Road Parkville, Melbourne Victoria, 3052.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Darzins</LastName><ForeName>Peteris</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Khalil</LastName><ForeName>Zeinab</ForeName><Initials>Z</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Gerontol A Biol Sci Med Sci</MedlineTA><NlmUniqueID>9502837</NlmUniqueID><ISSNLinking>1079-5006</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014665">Vasodilator Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>N9YNS0M02X</RegistryNumber><NameOfSubstance UI="D000109">Acetylcholine</NameOfSubstance></Chemical><Chemical><RegistryNumber>S07O44R1ZM</RegistryNumber><NameOfSubstance UI="D002211">Capsaicin</NameOfSubstance></Chemical><Chemical><RegistryNumber>S88TT14065</RegistryNumber><NameOfSubstance UI="D010100">Oxygen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000109" MajorTopicYN="N">Acetylcholine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001785" MajorTopicYN="N">Blood Gas Monitoring, Transcutaneous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002211" MajorTopicYN="N">Capsaicin</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017078" MajorTopicYN="N">Laser-Doppler Flowmetry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008833" MajorTopicYN="N">Microcirculation</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010100" MajorTopicYN="N">Oxygen</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010313" MajorTopicYN="N">Partial Pressure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011984" MajorTopicYN="N">Sensory Receptor Cells</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012867" MajorTopicYN="N">Skin</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="N">blood supply</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014665" MajorTopicYN="N">Vasodilator Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>4</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>6</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>4</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15814863</ArticleId><ArticleId IdType="pii">60/2/200</ArticleId><ArticleId IdType="doi">10.1093/gerona/60.2.200</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Darzins, Peteris" sort="Darzins, Peteris" uniqKey="Darzins P" first="Peteris" last="Darzins">Peteris Darzins</name><name sortKey="Khalil, Zeinab" sort="Khalil, Zeinab" uniqKey="Khalil Z" first="Zeinab" last="Khalil">Zeinab Khalil</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Ogrin, Rajna" sort="Ogrin, Rajna" uniqKey="Ogrin R" first="Rajna" last="Ogrin">Rajna Ogrin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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